Comments Off on Upcoming seminar at Techceuticals with Natoli: Solid Dosage Manufacturing Process July 19-21, 2022
Whether you are new to the industry or want additional functional knowledge, this course consists of a well-balanced combination of presentations, group discussions, Q&A sessions, and live demonstrations with hands-on exercises. During the training, you will enhance your knowledge of setup, operation, and maintenance procedures for manufacturing processing equipment, while learning other tooling options. With our help, your company can effectively reduce downtime and increase productivity.
Our Al Friedrich will cover #drygranulation foundational knowledge using #Alexanderwerk’s #rollercompactors.
Comments Off on Techceuticals and Natoli held Solid Dosage Manufacturing Process Seminar in Telford PA June 7-9, 2022
“When two exceptional training entities unite, you benefit!” was the motto of this seminar and it couldn’t have been more true. All the various processes helping push bulk material into pill form were covered. No wonder that all seats were sold out.
Our own Al Friedrich covered the #drygranulation via #rollercompactor. Theoretical training was followed up with practical demonstration using an #Alexanderwerk WP120 Pharma roller compactor.
Comments Off on Alexanderwerk will be presenting at the upcoming Techceuticals & Natoli Training: Tablet Development Process Training Seminar June 7-9, 2022
If you or your peers are in pharmaceutical, nutraceutical, CBD, or any other OSD related industry this is a great opportunity to learn about tableting. What is so great about our collaboration with this powerful training team is that experts as well as novices will be provided with powerful knowledge that can be put into action at home base right away. Your entire formulation, development, and manufacturing team can get on the same page. This type of training that incorporates fundamental theoretical knowledge and combining with practical hands on training in the lab is highly effective and might we say – fun! You get your questions answered on the spot and most importantly you get to network with other experts and people who are facing similar challenges as you.
Our Al Friedrich will be teaching the attendees about dry granulation using roller compaction. An Alexanderwerk WP120 Pharma will be featured in the lab for the live demonstration part.
Do not lose time and sign up right away and you may even get the early bird discounted rate.
Comments Off on Alexanderwerk helped co-author article featuring “Effect of deaeration on processability of poorly flowing powders by roller compaction” – link to article included
Our Al Friedrich helped co-author the article Effect of de-aeration on process ability of poorly flowing powders by roller compaction, we are pleased to let you know that the final version – containing full bibliographic details – is now available online for free for the next 50 days until June 30, 2022.
Dry granulation using a roller compactor is an important granulation technique for manufacturing pharmaceutical products as well as other materials. This study carried out at our academic research partner University of MN led by Prof. Sun focused on roller compaction (RC) of extremely cohesive powders. They can present a problem in roller compaction because they cannot be consistently fed into the slip and nip region of the rollers.
The use of a vacuum de-aeration mechanism, which is a standard offering on the Alexanderwerk roller compactors, can facilitate feeding of such difficult powders. This research was carried out using colloidal silica.
Cohesive pharmaceutical materials (low bulk density and cohesive powders) prepared by spray-drying, micronization, and freeze-drying are expected to benefit from the vacuum-aided powder feeding in RC.
Do you have such a challenging material and would like giving RC with vacuum de-aeration a try? We can offer our lab services and rental machines to you. Let’s talk! Please feel free to contact one of our local and global dry granulation experts where we can help you choose the best suitable granulation right from the beginning of your formulation process. https://alexanderwerkinc.com/contact-us/
Comments Off on How to Streamline Operations for Pharmaceutical CDMOs e-book released
At Alexanderwerk, we are the world’s leading provider of dry compaction and granulation solutions. We offer high-quality standard and custom machines that support critical processing applications in the chemical, pharmaceutical, food, life science, and nuclear fields. We just published an eBook in which we explore how to improve the value proposition a CDMO offers to its clients by taking advantage of our experience, process expertise, engineering, and test facilities. Among the topics covered:
If you have more specific questions chat with one of our subject matter experts in granulation development work, including roller compaction, blending, milling, drying and material handling, containment, continuous manufacturing and more use this link: https://alexanderwerkinc.com/contact-us/
Comments Off on Alexanderwerk will present Roller Compaction Scale Up De-mystified at the upcoming VP Pharma Expo February 22 10am-12pm ET
We are excited to examine the key parameters of roller compactor / dry granulation scale up and dispel prevalent myths and misconceptions with the international audience. Our Matt Walczer will be presenting and we will demonstrate the upscaling process with video feeds with a WP120 in our U.S. lab and a WP200 in our Remscheid, Germany lab. Do not miss the opportunity to attend this live presentation on Tuesday, February 22, 2022 from 10AM – 12PM Eastern Standard Time.
Comments Off on Alexanderwerk supports Natoli’s premier hands-on Cannabis Tablet Manufacturing Course – Jan 25-26 in Telford, PA
What you need to know for successful cannabis tablet production? That is the key question our partner Natoli Scientific will help answer during a 2-day-seminar on “Cannabis Oil, Powder Processing and Tablet Manufacturing Process”. Our experts from Alexanderwerk Inc. will support this premier hands-on training event covering #drygranulation of CBD powdered compounds.
Comments Off on Alexanderwerk roller compaction and dry granulation webinar with live lab feed will be held on 12/02/2021
Do not miss our webinar this Thursday 12/2/21 5pm EST intended for our customers, partners and friends in LATAM – organized by #Alexanderwerk and #PachecoYAndresen. The webinar will be held in English/ Spanish and will feature also a live demo from our lab in the US.
Comments Off on Alexanderwerk supports Natoli’s premier hands-on Cannabis Tablet Manufacturing Course – Dec. 7-8 in Telford, PA.
What you need to know for successful cannabis tablet production? That is the key question our partner Natoli Scientific will help answer during a 2-day-seminar on “Cannabis Oil, Powder Processing and Tablet Manufacturing Process”. Our experts from Alexanderwerk Inc. will support this premier hands-on training event covering #drygranulation.
Comments Off on Why Does Your Product Need Dry Granulation?
At Alexanderwerk, we partner with leaders across a range of industries, including pharmaceutical and chemical. Our expertise in dry granulation enables us to provide our customers with solutions for even the most complex powder handling processes. While we are headquartered in Germany, we efficiently serve our customers in Canada, the USA, and Mexico from our 17,000 square-foot facility in Pennsylvania. Offering extended services such as commissioning, calibration, training, and repair services, we consistently help our global customer base reap the many benefits of dry granulation.
The Process
To produce granules, there are two types of granulation processes: wet and dry. Wet granulation requires the addition of a liquid binder to form the granules, joining each individual particle together in a process known as agglomeration. Typically, wet granulation also necessitates a drying process to reduce the moisture within the granules. This can slow down the granulation process and may have a negative impact on the quality of the granules.
Dry granulation, on the other hand, does not require the manufacturer to add a liquid binder. This method utilizes a two-step process; first compacting and then milling the initial powder to create granules with the desired particle size distribution, and density. Most often, manufacturers will utilize roller compaction equipment, which functions by compressing the initial powder between two counter-rotating rollers.
While dry granulation is advantageous across an array of industries, there are some sectors that rely on it particularly heavily. These include:
The chemical industry
The pharmaceutical industry
The food and beverage industry
When or Why Is Dry Granulation Required?
Due to the fact that it does not require a liquid binding agent, dry granulation is highly beneficial for applications that utilize active pharmaceutical ingredients (APIs). This is because the addition of liquid and a heated drying process may reduce the efficacy of certain APIs. Furthermore, there are many products in the food and chemical industries that are also very heat sensitive. There are two types of material in particular that require the dry granulation process.
Moisture Sensitive Materials
Certain bulk materials, e.g APIs in the pharma industry, react negatively when they come in contact with moisture. This means that the API is at risk of losing vital chemical properties, thus rendering it ineffective. As these types of materials will not function after undergoing wet granulation, manufacturers must opt for dry granulation instead.
Temperature Sensitive Materials
Once a material has undergone the first step of the wet granulation process, the manufacturer must then put the material through a drying process. Even if a material can handle exposure to moisture, it must also be able to withstand high temperatures if it is to maintain its efficacy after it is dried. If the API in question is sensitive to temperatures, dry granulation is required.
Overall, regardless of the initial properties of the powder blend, the goal of dry granulation is to increase both the particle size and the bulk density of the powder. Both of these outcomes serve to improve the flow of distributed material, thus increasing the efficiency of the manufacturing process.
However, increased efficiency is just one of the advantages of dry granulation. A manufacturer or pharma CDMO may opt for dry granulation due to the fact that dry granulation machinery is smaller and requires minimal amounts of floor space. This process is also very flexible, as it functions well for both large and small volume runs. Additionally, dry granulation is significantly less likely to result in any type of alteration in drug morphology when compared to wet granulation.
Other advantages of dry granulation may include:
Improved blending and a fixed blend uniformity
Improved tablet disintegration time
Dense compaction
Reduced friability
Dust reduction
Reduction of material volume during handling and storage
Partner With Alexanderwerk for Your Dry Granulation Needs
Dry granulation is an efficient and reliable process with a variety of advantages. At Alexanderwerk, our specialists are well-versed in this process, and we work closely with our customers to find the appropriate solution and ensure optimal results for each unique application. Learn more about our dry granulation equipment, or contact us to discuss your project and schedule a consultation.
Let’s talk and collaborate with us helping solve your most difficult granulation challenges.
WP120 and WP200 Pharma in Alexanderwerk Inc’s Chem Lab
WP120 Pharma in Alexanderwerk Inc’s Pharma Lab
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