Interesting Insights

Continuous Dry Granulation by Roller Compaction

Continuous dry granulation by roller compaction is a well-established process in pharmaceutical, chemical and life science industry. In pharmaceutical applications the most common target is to increase the flowability of a powder or powder blend to enable the fast and homogeneous feeding of a tablet press. The challenge is to produce tablets of constant weight and sufficient strength, while maintaining an even distribution of the Active Pharmaceutical Ingredients (API). This can be achieved by roller compaction for a wide range of products and without the need of additional ingredients such as binders, moisture or lubricants. Furthermore, dry granulation by roller compaction is used to eliminate dust, increase the bulk density, reduce the storage volume, improve handling and manipulate the
dissolution properties.

Please feel free to download the following whitepaper to get more insights: “ShinEtsu – Protocol: Continuous Dry Granulation by Roller Compaction”.

Continuous Dry Granulation by Roller Compaction (1 download)

 

Video of a “Micro Batch”: